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Postdoctoral Research Associate-Bioanalytical Mass Spectrometry

Date: Mar 7, 2023

Location: Oak Ridge, TN, US, 37830

Company: Oak Ridge National Laboratory

Requisition Id 10311 


Oak Ridge National Laboratory is the largest US Department of Energy science and energy laboratory, conducting basic and applied research to deliver transformative solutions to compelling problems in energy and security. The work will explore how single cell mass spectrometry of metabolites can be used to provide insights into cell heterogeneity, drug activity, and cellular mechanisms. Efforts will focus on using atmospheric pressure liquid extraction mass spectrometry techniques to probe chemical localization, activity and heterogeneity in single cells. This work includes technique development, method development, and validation on model and real-world systems.


We are seeking a Postdoctoral Research Associate who will support the Bioanalytical Mass Spectrometry Group in the Biosciences Division (BSD), Biological and Environmental Systems Science Directorate (BESSD) at Oak Ridge National Laboratory (ORNL).


Major Duties/Responsibilities: 

  • Develop and evaluate new analytical approaches for atmospheric pressure liquid extraction mass spectrometry and apply them to study living biosystems
  • Develop assays to evaluate changing metabolomics, signaling pathways, and other biological processes in single cells to understand cellular heterogeneity.
  • Present and report research results at meetings and conferences and publish scientific results in peer-reviewed journals in a timely manner
  • Participate in the development of new research directions
  • Work with ORNL staff and other postdoctoral research associates and students to accomplish the research goals
  • Ensure compliance with environment, safety, health and quality program requirements
  • Maintain a strong commitment to the implementation and perpetuation of values and ethics


Basic Qualifications:

  • A PhD in Chemistry, Biochemistry, or a related field completed within the last 5 years


Preferred Qualifications:

  • Experience with mammalian cell culture, molecular staining, cell lysis and cell treatment protocols
  • Experience with mass spectrometry, with special emphasis on atmospheric pressure mass spectrometry of liquids
  • Experience in development of new analytical tools for biological systems
  • Experience with biological systems and biochemistry
  • Experience with high performance liquid chromatography mass spectrometry
  • Experience in data analysis
  • An excellent record of productive and creative research demonstrated by publications in peer-reviewed journals
  • Motivated and safety conscious
  • Excellent written and oral communication skills
  • Motivated self-starter with the ability to work independently and to participate creatively in collaborative teams across the laboratory
  • Ability to function well in a fast-paced research environment, set priorities to accomplish multiple tasks within deadlines, and adapt to ever-changing needs


Please submit three letters of reference when applying to this position. You can upload these directly to your application or have them sent to with the position title and number referenced in the subject line.


Instructions to upload documents to your candidate profile:

  • Login to your account via
  • View Profile
  • Under the My Documents section, select Add a Document


Applicants cannot have received their Ph.D. more than five years prior to the date of application and must complete all degree requirements before starting their appointment. The appointment length will be for up to 24 months with the potential for extension. Initial appointments and extensions are subject to performance and the availability of funding.


Moving can be overwhelming and expensive. UT-Battelle offers a generous relocation package to ease the transition process. Domestic and international relocation assistance is available for certain positions. If invited to interview, be sure to ask your Recruiter (Talent Acquisition Partner) for details.

For more information about our benefits, working here, and living here, visit the “About” tab at


Special Requirements

Export control, no clearance:  This position requires access to technology that is subject to export control requirements. Successful candidates must be qualified for such access without an export control license.


This position will remain open for a minimum of 5 days after which it will close when a qualified candidate is identified and/or hired.

We accept Word (.doc, .docx), Adobe (unsecured .pdf), Rich Text Format (.rtf), and HTML (.htm, .html) up to 5MB in size. Resumes from third party vendors will not be accepted; these resumes will be deleted and the candidates submitted will not be considered for employment.

If you have trouble applying for a position, please email

ORNL is an equal opportunity employer. All qualified applicants, including individuals with disabilities and protected veterans, are encouraged to apply.  UT-Battelle is an E-Verify employer.

Nearest Major Market: Knoxville