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R&D Associate in Radiotherapeutics

Date: Nov 6, 2021

Location: Oak Ridge, TN, US, 37830

Company: Oak Ridge National Laboratory

Requisition Id 6717 

The Isotope Applications Group at ORNL is seeking a highly motivated research scientist with experience in the areas of targeted radiotherapy, nanomedicine, or radiobiology. The Isotope Applications Research Group is involved in advancing radioisotope technologies, for medical, industrial, research and national security applications.


This position will focus on using nanotechnology to encapsulate radioisotopes for conjugation to targeting vectors and evaluating their effectiveness using in vitro cell models. The successful candidate should have a strong background in radiochemistry, inorganic chemistry, organic chemistry, nanotechnology, or radiobiology.


Major Duties and Responsibilities:

  • Design, implement novel methods of encapsulating alpha, beta, and Auger emitting radioisotopes within nano-constructs to enable conjugation to a variety of biological targeting molecules. 
  • Evaluate the targeting, DNA damage and cytotoxicity in a variety of cell model systems.
  • Perform data analysis
  • Participate in project planning and execution
  • Publish innovations, findings and reports in relevant conferences, journals and symposia.
  • Participate in project reviews, including presenting to internal and external technical review committees.
  • Ensure compliance with Environment, Safety and Health (ES&H) and QA requirements.
  • As a member of the ORNL scientific community, you will be expected to commit to ORNL's Research Code of Conduct. Our full code of conduct, and a statement by the Lab Director's office can be found here:


Basic Qualifications:

  • Requires a Ph.D. in Chemistry, Chemical Engineering, Nuclear Engineering, Biochemistry, Biotechnology, or related field with an emphasis in radiochemistry and/or radiobiology


Preferred Qualifications:

  • Experience in the synthesis and characterization of nanoparticles for medical applications
  • Experience working with 2D and 3D tumor model systems including cell spheroids, organoids or tissue chips.
  • Experience with various microscopy techniques, including SEM, TEM, confocal and fluorescent microscopy
  • A background in radiochemistry or radiobiology is desirable.
  • DNA damage, cytotoxicity, apoptosis and general biochemical assay experience
  • Experience working with alpha, beta or Auger emitting radioisotopes.
  • Excellent communication skills including verbal, presentation, and writing skills.
  • A demonstrated ability and hands-on experience with safe handling of highly radioactive samples is desired.
  • Evidence of peer-reviewed publications.


About the Isotope Science and Engineering Directorate (ISED):
Established in 2020, the Isotope Science and Engineering Directorate is strengthening Oak Ridge National Laboratory's leadership in isotope production and enrichment technology innovation. ISED is guiding the Lab's pursuit of the fundamental science and technology that broadens the application of isotopes for energy, environmental, medical, and national security purposes. These efforts are made possible through the High Flux Isotope Reactor, the Radiochemical Engineering Development Center, ORNL's other nuclear facilities, and an assemblage of world-leading scientists and engineers.  Please visit for more information about ISED.

Benefits at ORNL:
UT-Battelle offers a quality benefits package, including a matching 401(k), contributory pension plan, paid vacation, and medical/dental plan options.  Onsite amenities include a credit union, medical clinic, cafeteria, and fitness facilities.

Moving can be overwhelming and expensive.  UT-Battelle offers a generous relocation package to ease the transition process.  Domestic and international relocation assistance is available for certain positions.  If invited to interview, be sure to ask your Recruiter (Talent Acquisition Partner) for details.
For more information about our benefits, working here, and living here, visit the “About” tab at


This position will remain open for a minimum of 5 days after which it will close when a qualified candidate is identified and/or hired.

We accept Word (.doc, .docx), Adobe (unsecured .pdf), Rich Text Format (.rtf), and HTML (.htm, .html) up to 5MB in size. Resumes from third party vendors will not be accepted; these resumes will be deleted and the candidates submitted will not be considered for employment.

If you have trouble applying for a position, please email

ORNL is an equal opportunity employer. All qualified applicants, including individuals with disabilities and protected veterans, are encouraged to apply.  UT-Battelle is an E-Verify employer.

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